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Table 4 Comparison of LOQs for 16 PAHs achieved by GC–HRMS, GC–MS/MS and GC–MS

From: Optimized method for determination of 16 FDA polycyclic aromatic hydrocarbons (PAHs) in mainstream cigarette smoke by gas chromatography–mass spectrometry

Analytes

GC–HRMS

GC–MS/MS

GC–MS

LOQ, (ng/CFPa)

Estimated LOQ, (ng/cig)

LOQ, (ng/CFPa)

Estimated LOQ, (ng/cig)

LOQ, (ng/CFPa)

Estimated LOQ, (ng/cig)

Naphthalene

0.51

0.026

1178.71

58.94

108.17

5.41

Benzo[c]phenanthrene

0.04

0.002

ND

ND

66.80

3.34

Benzo[a]anthracene

0.03

0.002

38.57

1.93

38.11

1.91

Chrysene

0.04

0.002

50.13

2.51

49.61

2.48

Cyclopenta[c,d]pyrene

0.02

0.001

48.84

2.44

60.04

3.00

5-Methylchrysene

0.04

0.002

ND

ND

2.48

0.12

Benzo[b]fluoranthene

0.04

0.002

11.44

0.57

5.08

0.25

Benzo[k]fluoranthene

0.05

0.003

12.41

0.62

5.07

0.25

Benzo[j]aceanthrylene

0.09

0.005

ND

ND

ND

ND

Benzo[a]pyrene

0.04

0.002

5.01

0.25

3.03

0.15

Indeno[1,2,3-c,d]pyrene

0.02

0.001

5.46

0.27

1.54

0.08

Dibenzo[a,h]anthracene

0.07

0.004

0.83

0.04

1.48

0.07

Dibenzo[a,l]pyrene

0.05

0.003

ND

ND

ND

ND

Dibenzo[a,e]pyrene

0.04

0.002

0.80

0.04

0.28

0.01

Dibenzo[a,i]pyrene

0.06

0.003

1.33

0.07

ND

ND

Dibenzo[a,h]pyrene

0.07

0.004

2.99

0.15

ND

ND

  1. ND analyte not detected in the sample
  2. a20 cigarettes per CFP were smoked under ISO smoking regime