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Scheme 1 | Chemistry Central Journal

Scheme 1

From: Synthesis, characterization, molecular docking evaluation, antiplatelet and anticoagulant actions of 1,2,4 triazole hydrazone and sulphonamide novel derivatives

Scheme 1

Synthesis of 1,2,4-triazole hydrazone and 1,2,4-triazole sulphonamide derivatives: N-[{(2-phenyl)methylidene]-2-(4-cyclohexyl-5-(pyridine-3-yl)-4H-1,2,4-triazol-3-yl)sulfanyl}acetohydrazide (ZE-4a), N-[{(2-phenyl)methylidene]-2-(4-ethyl-5-(pyridine-2-yl)-4H-1,2,4-triazole-3-yl)sulfanyl}acetohydrazide (ZE-4b), N-[{(2-phenyl)methylidene]-2-(4-(fluorophenyl-5-(pyridine-2-yl)-4H-1,2,4-triazole-3yl)sulfanyl}acetohydrazide (ZE-4c), N-[{(4-methylphenyl) sulfonyl}]-2-(4-cyclohexyl-5-(pyridine-2-yl)-4H-1,2,4-triazole-3-yl)sulfanyl}acetohydrazide (ZE-5a), N-[{(4-methylphenyl) sulfonyl}-2-(4-ethyl-5-(pyridine-2-yl)-4H-1,2,4-triazole-3yl)sulfanyl}acetohydrazide (ZE-5b) and N-{(4-methylphenyl)sulfonyl]-2-(4-(4-flurophenyl-5-(pyridine-2-yl)-4H-1,2,4-triazol-3yl)sulfanyl}acetohydrazide (ZE-5c)

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