Fig. 1From: Determination of flutamide and two major metabolites using HPLC–DAD and HPTLC methodsScheme for preparation of Flu-3. Reagents and conditions: (a) NaOH, methanol, reflux, 3 h, (b) ICl, acetic acid, RT, 1.5 h; (c) aqueous NaOH, reflux, 24 hBack to article page