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Table 2 Intra-day and inter-day precision and accuracy of MST (QC) samples

From: LC–MS/MS method for the quantification of masitinib in RLMs matrix and rat urine: application to metabolic stability and excretion rate

Day of analysis

MST measured concentration

LQC (15 ng/mL)

MQC (50 ng/mL)

HQC (150 ng/mL)

Day 1

15.06

48.40

152.68

14.81

47.92

152.32

14.77

47.98

151.63

14.79

48.08

152.56

14.62

48.36

151.58

14.73

48.20

148.58

14.59

47.80

152.02

14.61

47.94

150.70

14.68

47.83

152.89

14.70

48.04

152.10

14.65

47.46

151.61

14.50

47.87

151.63

Day 2

14.56

47.90

151.42

14.59

47.36

150.52

14.74

46.78

150.20

14.63

46.68

148.79

14.67

46.77

149.41

14.72

46.64

149.89

Day 3

14.50

46.84

150.12

14.42

46.51

148.57

14.47

46.62

149.65

14.42

46.34

147.33

14.50

46.66

147.88

14.50

46.34

147.79

 

LQC (15 ng/mL)

MQC (50 ng/mL)

HQC (150 ng/mL)

Intra-day assaya

Inter-day assayb

Intra-day assay

Inter-day assay

Intra-day assay

Inter-day assay

Mean

14.71

14.63

47.99

47.39

151.69

150.49

Standard deviation (SD)

0.14

0.15

0.26

0.71

1.15

1.69

Precision (%RSD)

0.95

1.01

0.54

1.49

0.76

1.12

Accuracy (%RE)

− 1.93

− 2.43

− 4.02

− 5.22

1.13

0.33

  1. aAverage of twelve determinations of day 1
  2. bAverage of six determinations in three consecutive days
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BMC Chemistry

ISSN: 2661-801X

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