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Table 3 Scope in pyridine analogues for nucleophilic aromatic substitution

From: An improved solvent-free synthesis of flunixin and 2-(arylamino) nicotinic acid derivatives using boric acid as catalyst

Entry Substrate Nucleophile Time (h) Yield (%)
1 12
2 12
3 12
  1. Reaction conditions: aniline (2 mmol), pyridine analogues (1 mmol), and 20 mg (0.3 mmol) H3BO3 at 120 °C under solvent-free condition