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Table 3 In vitro anti-malarial activity of diethyl 4-(4-(((3-aryl-1-phenyl-1H-pyrazol-4-yl)methyleneaminocarbamoyl)methoxy)phenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (5a5g)

From: Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents

Compound IC50 nM IC90 nM IC95 nM IC99 nM
5a 16.87 7.98 8.64 9.14
5b 8.66 3.81 5.60 7.88
5c 8.08 3.98 4.36 4.64
5d 4.40 1.22 1.8 2.31
5e 10.49 4.72 6.21 7.87
5f 9.94 3.98 4.29 4.53
5g 9.94 3.85 5.37 7.58
Chloroquine 18.7
Pyrimethamine 11
Artemisinin 6