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Table 3 In vitro anti-malarial activity of diethyl 4-(4-(((3-aryl-1-phenyl-1H-pyrazol-4-yl)methyleneaminocarbamoyl)methoxy)phenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (5a–5g)

From: Design, synthesis, conformational and molecular docking study of some novel acyl hydrazone based molecular hybrids as antimalarial and antimicrobial agents

Compound

IC50 nM

IC90 nM

IC95 nM

IC99 nM

5a

16.87

7.98

8.64

9.14

5b

8.66

3.81

5.60

7.88

5c

8.08

3.98

4.36

4.64

5d

4.40

1.22

1.8

2.31

5e

10.49

4.72

6.21

7.87

5f

9.94

3.98

4.29

4.53

5g

9.94

3.85

5.37

7.58

Chloroquine

18.7

–

–

–

Pyrimethamine

11

–

–

–

Artemisinin

6

–

–

–