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Table 1 Cytotoxicity of test compounds against HT-1080 cells

From: Synthesis and anticancer activity of novel quinazolinone-based rhodanines

Code R1 R2 HT-1080
31 H H 42.9 (± 17.3)
32 4-F H 47.3 (± 0.3)
33 4-Cl H 35.3 (± 4.6)
34 3-Cl H 57.1 (± 9.2)
35 4-Br H 28.8 (± 2.4)
36 3-Br H 43.4 (± 6.7)
37 4-CF3 H 15.8 (± 2.1)
38 4-CH3 H 35.7 (± 5.9)
39 3-CH3 H 47.5 (± 12.1)
40 4-OCH3 H 36.4 (± 0.9)
41 H OCH3 36.1 (± 2.9)
42 4-F OCH3 35.8 (± 11.8)
43 4-Cl OCH3 10.2 (± 4.7)
44 3-Cl OCH3 28.4 (± 9.4)
45 4-Br OCH3 8.7 (± 3.6)
46 3-Br OCH3 23.7 (± 0.6)
47 4-CF3 OCH3 15.8 (± 2.1)
48 4-CH3 OCH3 31.5 (± 4.1)
49 3-CH3 OCH3 30.7 (± 1.1)
50 4-OCH3 OCH3 34.7 (± 2.7)
Doxorubicin 0.012 (± 0.005)
  1. IC50s (μM), mean of three independent experiments (± standard deviation)