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Scheme 1 | Chemistry Central Journal

Scheme 1

From: Synthesis and biological evaluation of tricyclic matrinic derivatives as a class of novel anti-HCV agents

Scheme 1

Synthetic procedures of methyl matrinate and matrinol derivatives. Reagents and conditions: (a) 5 N NaOH, reflux, 9 h, 6 N HCl, pH = 5–6; (b) 2 N MeOH/HCl, reflux, 2 h; (c) RBr, K2CO3, MeCN, r.t., overnight; (d) LiAlH4, THF, r.t., 30 min; (e) R2MgCl, THF, 0–25 °C, reflux, 2 h; (f) TsCl, CH2Cl2, TEA, 4-DMAP; (g) alkylmagnesium chloride, THF, reflux, 2 h

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