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Table 5 Assay results for the determination of the studied drugs in different synthetic mixtures in different pharmaceutical ratios

From: Simultaneous determination of cetirizine, phenyl propanolamine and nimesulide using third derivative spectrophotometry and high performance liquid chromatography in pharmaceutical preparations

Parameter

Amount taken (μg/mL)

Proposed method

Comparison methods [6, 15]

Amount found (μg/mL)

% Found

Amount taken (μg/mL)

% Found

CTZ

PPA

NMS

CTZ

PPA

NMS

CTZ

PPA

NMS

CTZ

PPA

NMS

CTZ

PPA

NMS

3rd Derivative method

8.0

40.0

160.0

7.8

40.0

157.0

97.5

100.0

98.13

5.00

10.0

15.0

99.18

99.77

101.3

9.0

45.0

180.0

8.8

45.0

180.5

98.89

100.0

100.3

5.50

11.0

16.5

100.3

100.9

100.5

10.0

50.0

200.0

9.7

49.0

199.0

98.0

98.00

99.50

6.00

12.0

18.0

101.8

99.43

98.99

12.0

24.0

36.0

12.2

23.5

40.0

101.7

97.92

100.0

8.00

8.00

8.00

98.09

99.81

99.49

40.0

40.0

40.0

39.1

40.0

40.0

100.0

100.0

100.0

10.0

10.0

10.0

100.7

99.77

99.63

Mean

      

99.21

98.18

99.59

   

100.0

99.94

99.98

± S.D.

      

1.67

1.18

0.95

   

1.54

0.80

0.34

t

      

1.22

0.139

0.70

      

F

      

1.39

1.16

1.12

      

HPLC method

5.0

25.0

100.0

4.89

39.95

98.44

97.70

100.2

98.44

5.00

10.0

15.0

99.18

99.77

101.3

5.5

27.5

110.0

5.57

44.11

110.2

101.3

100.6

100.2

5.50

11.0

16.5

100.3

100.9

100.5

6.0

30.0

120.0

6.02

50.60

121.05

100.4

99.45

100.9

6.00

12.0

18.0

101.8

99.43

98.99

12.0

24.0

36.00

12.0

23.7

36.64

100.3

99.64

101.8

8.00

8.00

8.00

98.09

99.81

99.49

40.0

40.0

40.00

39.9

39.5

39.69

99.98

99.98

99.25

10.0

10.0

10.0

100.7

99.77

99.63

Mean

      

99.91

99.97

100.1

   

100.0

99.94

99.98

± S.D.

      

0.55

0.53

1.06

   

1.57

0.80

0.34

t

      

0.14

0.122

0.24

      

F

      

1.16

1.51

2.1

      
  1. Each result is the average of three separate determinations
  2. The value of tabulated t and F are 2.13 and 6.4 respectively at P = 0.05