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Table 5 Assay results for the determination of the studied drugs in different synthetic mixtures in different pharmaceutical ratios

From: Simultaneous determination of cetirizine, phenyl propanolamine and nimesulide using third derivative spectrophotometry and high performance liquid chromatography in pharmaceutical preparations

Parameter Amount taken (μg/mL) Proposed method Comparison methods [6, 15]
Amount found (μg/mL) % Found Amount taken (μg/mL) % Found
CTZ PPA NMS CTZ PPA NMS CTZ PPA NMS CTZ PPA NMS CTZ PPA NMS
3rd Derivative method 8.0 40.0 160.0 7.8 40.0 157.0 97.5 100.0 98.13 5.00 10.0 15.0 99.18 99.77 101.3
9.0 45.0 180.0 8.8 45.0 180.5 98.89 100.0 100.3 5.50 11.0 16.5 100.3 100.9 100.5
10.0 50.0 200.0 9.7 49.0 199.0 98.0 98.00 99.50 6.00 12.0 18.0 101.8 99.43 98.99
12.0 24.0 36.0 12.2 23.5 40.0 101.7 97.92 100.0 8.00 8.00 8.00 98.09 99.81 99.49
40.0 40.0 40.0 39.1 40.0 40.0 100.0 100.0 100.0 10.0 10.0 10.0 100.7 99.77 99.63
Mean        99.21 98.18 99.59     100.0 99.94 99.98
± S.D.        1.67 1.18 0.95     1.54 0.80 0.34
t        1.22 0.139 0.70       
F        1.39 1.16 1.12       
HPLC method 5.0 25.0 100.0 4.89 39.95 98.44 97.70 100.2 98.44 5.00 10.0 15.0 99.18 99.77 101.3
5.5 27.5 110.0 5.57 44.11 110.2 101.3 100.6 100.2 5.50 11.0 16.5 100.3 100.9 100.5
6.0 30.0 120.0 6.02 50.60 121.05 100.4 99.45 100.9 6.00 12.0 18.0 101.8 99.43 98.99
12.0 24.0 36.00 12.0 23.7 36.64 100.3 99.64 101.8 8.00 8.00 8.00 98.09 99.81 99.49
40.0 40.0 40.00 39.9 39.5 39.69 99.98 99.98 99.25 10.0 10.0 10.0 100.7 99.77 99.63
Mean        99.91 99.97 100.1     100.0 99.94 99.98
± S.D.        0.55 0.53 1.06     1.57 0.80 0.34
t        0.14 0.122 0.24       
F        1.16 1.51 2.1       
  1. Each result is the average of three separate determinations
  2. The value of tabulated t and F are 2.13 and 6.4 respectively at P = 0.05