Simultaneous determination of cetirizine, phenyl propanolamine and nimesulide using third derivative spectrophotometry and high performance liquid chromatography in pharmaceutical preparations

Table 4 Precision data for the determination of the studied drugs by the proposed methods

Parameters	Intra-day			Inter-day
Parameters	\(\overline{\text{x}} \pm {\text{S}} . {\text{D}}\)	% RSD	% Error	\(\overline{\text{x}} \pm {\text{S}} . {\text{D}}\)	% RSD	% Error
3rd Derivative method
CTZ (μg/mL)
8	99.04 ± 1.04	1.05	0.61	100.05 ± 0.24	0.24	0.14
20	98.04 ± 0.45	0.46	0.27	98.8 ± 0.27	0.27	0.16
40	97.65 ± 0.53	0.54	0.31	98.93 ± 0.25	0.25	0.15
PPA (μg/mL)
20	98.89 ± 1.27	1.29	0.74	99.08 ± 0.85	0.86	0.49
50	100.7 ± 1.85	1.84	1.06	99.99 ± 1.42	1.42	0.82
100	99.2 ± 1.83	1.85	1.07	100.59 ± 1.18	1.17	0.68
NMS (μg/mL)
40	98.23 ± 0.77	0.79	0.45	99.27 ± 1.09	1.1	0.63
100	99.27 ± 1.22	1.32	0.71	100.6 ± 0.6	0.60	0.34
120	98.32 ± 0.62	0.63	0.36	99.91 ± 1.02	1.02	0.59
HPLC method
CTZ (μg/mL)
8	98.63 ± 0.95	0.96	0.56	100.53 ± 0.68	0.67	0.39
20	98.87 ± 0.49	0.50	0.29	100.75 ± 0.4	0.39	0.23
40	98.18 ± 0.47	0.48	0.27	98.15 ± 1.1	1.12	0.65
PPA (μg/mL)
20	98.23 ± 0.55	0.56	0.32	99.53 ± 0.49	0.5	0.29
50	98.07 ± 0.15	0.16	0.09	99.88 ± 0.17	0.17	0.10
100	98.23 ± 0.83	0.83	0.49	98.94 ± 0.21	0.22	0.12
NMS (μg/mL)
40	98.52 ± 0.62	0.63	0.36	98.77 ± 0.42	0.42	0.24
100	98.67 ± 0.36	0.36	0.21	99.45 ± 0.52	0.52	0.30
120	98.52 ± 0.95	0.96	0.55	100.24 ± 0.87	0.87	0.5

ISSN: 2661-801X