Skip to main content

Table 3 Assay results for the determination of the studied drugs in pure form by the proposed and comparison methods

From: Simultaneous determination of cetirizine, phenyl propanolamine and nimesulide using third derivative spectrophotometry and high performance liquid chromatography in pharmaceutical preparations

Compound

3rd derivative method

HPLC method

Comparison methods [6, 15]

Amount taken (μg/mL)

Amount found (μg/mL)

% Found

Amount taken (μg/mL)

Amount found (μg/mL)

% Found

Amount taken (μg/mL)

Amount found (μg/mL)

% Found

CTZ

8.00

7.9

98.75

5.00

4.905

98.10

5.00

4.98

99.58

10.00

10.00

100.00

6.00

5.918

98.63

7.00

7.04

100.59

16.00

16.9

99.38

8.00

8.036

100.45

9.00

8.98

99.77

50.00

49.0

98.00

10.00

10.051

100.51

   

60.00

59.9

99.83

20.00

20.172

100.86

   

90.00

88.00

97.78

40.00

39.918

99.80

   

Mean

  

98.96

  

99.73

  

99.98

± S.D.

  

0.94

  

0.44

  

0.58

t

  

1.72

  

0.365

   

F

  

3.04

  

4.36

   

PPA

20.00

20.00

100.0

10.00

9.842

98.42

10.00

9.898

98.98

30.00

29.57

98.58

25.00

24.932

99.73

11.00

11.204

101.85

40.00

39.5

98.75

30.00

30.334

101.11

12.00

11.898

99.15

50.00

48.5

97.00

35.00

34.263

97.89

   

80.00

78.5

98.13

50.00

50.877

101.75

   

100.00

99.0

99.0

100.0

99.8

99.75

   

Mean

  

98.58

  

99.78

  

99.99

± S.D.

  

1.23

  

1.49

  

1.61

t

  

1.66

  

0.203

   

F

  

2.60

  

1.17

   

NMS

20.00

20.0

100.0

10.00

10.10

101.07

50.00

50.71

101.42

30.00

29.50

98.33

30.00

30.257

100.86

70.00

68.82

98.31

40.00

39.00

97.50

40.00

40.254

100.64

100.00

100.47

100.47

100.00

100.5

100.5

50.00

49.482

98.96

   

180.00

179.50

99.72

100.00

99.048

99.05

   

200.00

198.00

99.00

120.00

120.85

100.71

   

Mean

  

99.18

  

100.22

  

100.07

± S.D.

  

1.28

  

1.1

  

1.53

t

  

0.989

  

0.179

   

F

  

2.02

  

2.8

   
  1. Each result is the average of three separate determinations
  2. The value of tabulated t and F are 2.20 and 19.29, respectively at P = 0.05 [21]