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Table 3 Assay results for the determination of the studied drugs in pure form by the proposed and comparison methods

From: Simultaneous determination of cetirizine, phenyl propanolamine and nimesulide using third derivative spectrophotometry and high performance liquid chromatography in pharmaceutical preparations

Compound 3rd derivative method HPLC method Comparison methods [6, 15]
Amount taken (μg/mL) Amount found (μg/mL) % Found Amount taken (μg/mL) Amount found (μg/mL) % Found Amount taken (μg/mL) Amount found (μg/mL) % Found
CTZ 8.00 7.9 98.75 5.00 4.905 98.10 5.00 4.98 99.58
10.00 10.00 100.00 6.00 5.918 98.63 7.00 7.04 100.59
16.00 16.9 99.38 8.00 8.036 100.45 9.00 8.98 99.77
50.00 49.0 98.00 10.00 10.051 100.51    
60.00 59.9 99.83 20.00 20.172 100.86    
90.00 88.00 97.78 40.00 39.918 99.80    
Mean    98.96    99.73    99.98
± S.D.    0.94    0.44    0.58
t    1.72    0.365    
F    3.04    4.36    
PPA 20.00 20.00 100.0 10.00 9.842 98.42 10.00 9.898 98.98
30.00 29.57 98.58 25.00 24.932 99.73 11.00 11.204 101.85
40.00 39.5 98.75 30.00 30.334 101.11 12.00 11.898 99.15
50.00 48.5 97.00 35.00 34.263 97.89    
80.00 78.5 98.13 50.00 50.877 101.75    
100.00 99.0 99.0 100.0 99.8 99.75    
Mean    98.58    99.78    99.99
± S.D.    1.23    1.49    1.61
t    1.66    0.203    
F    2.60    1.17    
NMS 20.00 20.0 100.0 10.00 10.10 101.07 50.00 50.71 101.42
30.00 29.50 98.33 30.00 30.257 100.86 70.00 68.82 98.31
40.00 39.00 97.50 40.00 40.254 100.64 100.00 100.47 100.47
100.00 100.5 100.5 50.00 49.482 98.96    
180.00 179.50 99.72 100.00 99.048 99.05    
200.00 198.00 99.00 120.00 120.85 100.71    
Mean    99.18    100.22    100.07
± S.D.    1.28    1.1    1.53
t    0.989    0.179    
F    2.02    2.8    
  1. Each result is the average of three separate determinations
  2. The value of tabulated t and F are 2.20 and 19.29, respectively at P = 0.05 [21]