From: Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives
IL-1β (pg/mL)
COX2 (ng/mL)
PGE2 (pg/mL)
Control (vehicle)
26.8 ± 1.4
15.9 ± 0.4
17.3 ± 0.9
CFA
93 ± 2.2a
46.3 ± 1.5a
65.9 ± 2.3a
Compound 9
37.4 ± 1.1a,b
16.9 ± 0.7b
22.6 ± 0.7b
Compound 15
41.9 ± 0.9a,b
20.8 ± 0.5a,b
25.4 ± 0.3a,b