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Table 2 Effect of test compounds 50 mg/kg on serum IL-1β, COX2 and PGE2 of rat CFA

From: Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives

 

IL-1β (pg/mL)

COX2 (ng/mL)

PGE2 (pg/mL)

Control (vehicle)

26.8 ± 1.4

15.9 ± 0.4

17.3 ± 0.9

CFA

93 ± 2.2a

46.3 ± 1.5a

65.9 ± 2.3a

Compound 9

37.4 ± 1.1a,b

16.9 ± 0.7b

22.6 ± 0.7b

Compound 15

41.9 ± 0.9a,b

20.8 ± 0.5a,b

25.4 ± 0.3a,b

  1. Data represent the mean ± SEM (n = 6 for each group)
  2. aSignificance versus control (P ≤ 0.05)
  3. bSignificance versus CFA group (P ≤ 0.05)