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Fig. 5 | Chemistry Central Journal

Fig. 5

From: Synthesis, crystallographic characterization, molecular docking and biological activity of isoquinoline derivatives

Fig. 5

a Binding mode of indomethacin co-crystallized with COX-2 as 3D (left) and 2D (right), PDB entry 4COX. b Binding mode of naproxen co-crystallized inside COX-2 active site as 3D (left) and 2D (right), PDB entry 3NT1. Pharmacophore features created using LigandScout. Red arrows: H-bonds, red star: negative ionizable feature, yellow spheres: hydrophobic contacts

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BMC Chemistry

ISSN: 2661-801X

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