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Table 2 Base and solvent effects on the Suzuki coupling of p-bromoacetophenone (5) with phenylboronic acid (6) under thermal conditions

From: Novel pyridine-based Pd(II)-complex for efficient Suzuki coupling of aryl halides under microwaves irradiation in water

Entry

Base

Solvent

Yield %a,b

1

KOH

H20 (TBAB)

100 (96)

2

KOH

H20 (CTAB)

100 (92)

3

K2C03

H20 (TBAB)

100 (94)

4

KOH

DMF

80 (51)

5

K2C03

DMF

80 (61)

6

KOH

Toluene

100 (91)

7

KOH

THF

60 (50)

  1. aConditions: p-Bromoacetophenone: 1 mmol; phenylboronic acid: 1.2 mmol; TBAB or CTAB: 0.6 mmol; base: 2 mmol; solvent: 5 mL, Pd-complex 4: 0.25 mol%, heating for 2 h at 160 °C (H2O and DMF), 130 °C (Toluene) and at 90 °C (THF)
  2. bConversions were based on GC-analysis and the values between parenthesis refer to the isolated yields