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Table 5 Synthesis of pivalic acid amides 2426

From: Formation of amides: one-pot condensation of carboxylic acids and amines mediated by TiCl4

Entry

R1

R2

R3

 

Product

Yield (%)a

x

(CH3)3C

H

C6H5

24

90

y

(CH3)3C

H

C3H7

25

75

z

(CH3)3C

C2H5

C2H5

26

9

  1. aIsolated yields