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Table 1 Protective effect of compounds and omeprazole against ethanol-induced gastric ulcers in rats

From: Synthesis, characterization, anti-ulcer action and molecular docking evaluation of novel benzimidazole-pyrazole hybrids

Treatment

Ulcer index

% Inhibition

Saline 10 mL/kg + Ethanol (1 mL/100 g)

4.99 ± 0.007

–

Compund 5a (100 µg/kg) + Ethanol (1 mL/100 g)

3.22 ± 0.009***

35.4

Compound 5a (500 µg/kg) + Ethanol (1 mL/100 g)

1.07 ± 0.008***

78.5

Compund 5b (100 µg/kg) + Ethanol (1 mL/100 g)

3.48 ± 0.008***

30.2

Compound 5b (500 µg/kg) + Ethanol (1 mL/100 g)

1.26 ± 0.009***

74.7

Compund 5c (100 µg/kg) + Ethanol (1 mL/100 g)

3.52 ± 0.009***

29.4

Compound 5c (500 µg/k g) + Ethanol (1 mL/100 g)

1.48 ± 0.009***

70.3

Compund 5d (100 µg/kg) + Ethanol (1 mL/100 g)

3.09 ± 0.007***

38.1

Compound 5d (500 µg/kg) + Ethanol (1 mL/100 g)

0.84 ± 0.017***

83.1

Compund 5e (100 µg/kg) + Ethanol (1 mL/100 g)

3.18 ± 0.01***

36.2

Compound 5e (500 µg/kg) + Ethanol (1 mL/100 g)

1.06 ± 0.01***

79

Compund 5f (100 µg/kg) + Ethanol (1 mL/100 g)

3.75 ± 0.016***

24.8

Compound 5f (500 µg/kg) + Ethanol (1 mL/100 g)

1.39 ± 0.02***

72.1

Omeprazole (30 mg/kg) + Ethanol (1 mL/100 g)

0.84 ± 0.01***

83.1

  1. *** P < 0.001 compared to control saline group, one-way analysis of variance with post hoc Tukey test, n = 5
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BMC Chemistry

ISSN: 2661-801X

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