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Table 3 Inhibition activities of 7, 13–15, and sunitinib against in vitro tube formation

From: Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitors

Compound

R

IC50 (μM)

Area

Sunitinib

–

1.54 ± 0.08

7

–SO2N(CH2CH2Cl)2

0.76 ± 0.11

13

–OMe

0.74 ± 0.16

14

–OH

0.62 ± 0.07

15

–SH

0.53 ± 0.11

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BMC Chemistry

ISSN: 2661-801X

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