Fig. 6From: Structural optimization and evaluation of novel 2-pyrrolidone-fused (2-oxoindolin-3-ylidene)methylpyrrole derivatives as potential VEGFR-2/PDGFRβ inhibitorsSunitinib, 7, and 13–15 are docked into the active site of VEGFR-2 (PDB ID: 4AGD) in 3-dimentional structure. a Sunitinib in VEGFR-2; b 7 in VEGFR-2; c 7 in VEGFR-2 (the active site of VEGFR-2 was shown in hydrophobicity maps); d 13 in VEGFR-2; e 14 in VEGFR-2, f 15 in VEGFR-2. Compounds are showed in sticks; hydrogen bonds are shown as dashed yellow line; pi–pi interaction is shown in orange line; shades of brown indicate regions of high hydrophobicity; shades of white indicate regions of neutral, shades of blue indicate regions of low hydrophobicityBack to article page