Fig. 12
From: Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K
Distribution of residues possibly associated with receptor binding and biological activity of HR insulin, Insugen (I). The major concentration of residues occurs on chain B (blue) which includes the residue Phe25B discussed in the definitive account of the porcine insulin X-ray structure by Baker et al. [1]. In the Insugen (I) structure Phe25B occupies two distinct well defined conformations as shown here. It is of interest to note that in Intergen (II) HR insulin Phe25B has a clear well defined conformation. Alternative conformations in Insugen (I) residues are coloured blue here. A minor group of residues occurs on chain C (coloured grey). Drawn with Accelrys Discovery Studio 3 [23]