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Table 3 Antimycobacterial activity data of target compounds (5a5n) by microdilution method

From: Novel drug targets for Mycobacterium tuberculosis: 2-heterostyrylbenzimidazoles as inhibitors of cell wall protein synthesis

Compounds MIC (lMC) MTB H37Rv Clinical isolate of MTB
15th day 21 days 15th day 21 days
5a NA NA NA NA
5b NA NA NA NA
5c NA NA NA NA
5d 8 8 8 8
5e 8 8 16 16
5f 16 16 16 16
5g 31 31 NA NA
5h NA NA NA NA
5i 8 8 8 8
5j NA NA NA NA
5k NA NA NA NA
5l 16 16 NA NA
5m NA NA NA NA
5n NA NA NA NA
INH 0.28 0.28 8 8
R 0.09 0.09 2 2
S 2 2 2 2
E 4 4 4 4
  1. Controles used were first line drugs INH-isoniazid
  2. S Streptomycin, E Ethambutol, R Rifampicin, NA compound was not active TB isolates