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Table 1 Synthesis of target compounds (5a5n)

From: Novel drug targets for Mycobacterium tuberculosis: 2-heterostyrylbenzimidazoles as inhibitors of cell wall protein synthesis

Entry Target compounds Method-1 (diamine + cinnamic acid) Method-2 (2-MeBz + aldehydes) m.p (°C)
Time (h) Temp (°C) Yield (%) Time (h) Temp (°C) Yield (%)  
5a 5 160 74 6 160 75 202–204
5b 5 160 68 6 160 70 178–180
5c 5 160 80 6 160 76 130–132
5d 5 150 73 6 160 76 210–212
5e 5 150 78 6 160 76 198–200
5f 5 160 74 5 160 76 >240
5g 5 160 68 5 150 66 100–102
5h 5 150 78 5 150 74 108–110
5i 5 160 75 5 150 75 >220
5j 5 150 76 6 160 74 200–220
5k 6 160 75 5 150 75 190–210
5l 5 150 75 6 160 74 202–204
5m 5 160 74 5 150 75 205–210
5n 6 150 75 6 160 75 210–220