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Table 1 Synthesis of target compounds (5a5n)

From: Novel drug targets for Mycobacterium tuberculosis: 2-heterostyrylbenzimidazoles as inhibitors of cell wall protein synthesis

Entry

Target compounds

Method-1 (diamine + cinnamic acid)

Method-2 (2-MeBz + aldehydes)

m.p (°C)

Time (h)

Temp (°C)

Yield (%)

Time (h)

Temp (°C)

Yield (%)

 

5a

5

160

74

6

160

75

202–204

5b

5

160

68

6

160

70

178–180

5c

5

160

80

6

160

76

130–132

5d

5

150

73

6

160

76

210–212

5e

5

150

78

6

160

76

198–200

5f

5

160

74

5

160

76

>240

5g

5

160

68

5

150

66

100–102

5h

5

150

78

5

150

74

108–110

5i

5

160

75

5

150

75

>220

5j

5

150

76

6

160

74

200–220

5k

6

160

75

5

150

75

190–210

5l

5

150

75

6

160

74

202–204

5m

5

160

74

5

150

75

205–210

5n

6

150

75

6

160

75

210–220