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Scheme 1 | Chemistry Central Journal

Scheme 1

From: One pot synthesis, antimicrobial and antioxidant activities of fused uracils: pyrimidodiazepines, lumazines, triazolouracil and xanthines

Scheme 1

Reagents and conditions: a NCCH2COOEt, EtONa, Reflux; b NaNO2, HCl, rt; c (NH4)2S; d ArCH=C(CN)COOEt, TEA, DMF, Reflux. [5a (R=H, 66%); 5b (R=4−Cl, 57%); 5c (R=4−Br, 57%); 5d (R=2−OH, 51%); 5e (R = 3−NO2, 49%)]; e ArCH=C(CN)2, TEA, DMF, Reflux. [6a (R=H, 53%); 6b (R=4−Cl, 69%); 6c (R=4−Br, 64%); 6d (R=2−OH, 54%)]

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