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Fig. 8 | Chemistry Central Journal

Fig. 8

From: Antiproliferative and apoptotic effects of black turtle bean extracts on human breast cancer cell line through extrinsic and intrinsic pathway

Fig. 8

Effect of BTB extracts on Bcl-2, Bax and Bcl-xL in MCF-7 and MDA-MB231 cells (a) on genes (mRNA) expression by PCR in MCF-7: lane 1 (untreated); lane 2 and 3 treated with 50 and 100 μg/ml respectively. MDA-MB231: lane 4 (untreated); lane 5 and 6 treated with 50 and 100 μg/ml respectively. b On mRNA expression by real time PCR of intrinsic apoptotic signalling molecules on cells; change in the expression of Bcl-xL (i) and Bax (ii) genes in both breast cancer cells in a dose dependent manner, (iii) Bcl-2 was decreased with the increasing concentration of BTB extract

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