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Table 4 VNT stability data in plasma matrix under different conditions

From: Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

Nominal concentration (ng/mL)

Mean (ng/mL)

Recovery %

Precision (% RSD)

Room temp. for 8 h

 20

18.77 ± 0.58

93.84

3.08

 150

148.23 ± 1.84

98.82

1.24

 400

396.81 ± 5.55

99.20

1.40

Three freeze–thaw cycles

 20

18.98 ± 0.42

94.89

2.22

 150

150.03 ± 1.28

100.02

0.86

 400

397.17 ± 6.35

99.29

1.60

Stored at 4 °C for 24 h

 20

19.00 ± 0.32

95.02

1.70

 150

149.06 ± 1.55

99.37

1.04

 400

397.22 ± 5.92

99.31

1.49

Stored at −20 °C for 30 days

 20

19.00 ± 0.32

94.98

1.67

 150

147.82 ± 0.96

98.55

0.65

 400

395.48 ± 4.69

98.87

1.19