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Table 4 VNT stability data in plasma matrix under different conditions

From: Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

Nominal concentration (ng/mL) Mean (ng/mL) Recovery % Precision (% RSD)
Room temp. for 8 h
 20 18.77 ± 0.58 93.84 3.08
 150 148.23 ± 1.84 98.82 1.24
 400 396.81 ± 5.55 99.20 1.40
Three freeze–thaw cycles
 20 18.98 ± 0.42 94.89 2.22
 150 150.03 ± 1.28 100.02 0.86
 400 397.17 ± 6.35 99.29 1.60
Stored at 4 °C for 24 h
 20 19.00 ± 0.32 95.02 1.70
 150 149.06 ± 1.55 99.37 1.04
 400 397.22 ± 5.92 99.31 1.49
Stored at −20 °C for 30 days
 20 19.00 ± 0.32 94.98 1.67
 150 147.82 ± 0.96 98.55 0.65
 400 395.48 ± 4.69 98.87 1.19