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Table 3 Recovery of quality control samples for determining the concentration of VNT in human plasma and RLMs matrices

From: Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

Nominal concentration (ng/mL) Human plasma RLMs
20 ng/mL 150 ng/mL 400 ng/mL 20 ng/mL 150 ng/mL 400 ng/mL
Meana 19.36 150.78 400.38 19.47 151.59 402.51
Recovery (%) 96.80 100.52 100.10 97.35 101.06 100.63
Standard deviation (SD) 0.43 1.29 6.4 0.31 0.5 3.47
Precision (% RSD) 2.22 0.86 1.6 1.61 0.33 0.86
  1. aAverage of six determinations