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Table 2 Intra-day and inter-day precision and accuracy of the proposed methods

From: Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

  LQC (20 ng/mL) MQC (150 ng/mL) HQC (400 ng/mL)
Intra-day assaya Inter-day assayb Intra-day assay Inter-day assay Intra-day assay Inter-day assay
Human plasma matrix
 Mean 19.01 19.22 148.71 148.59 397.28 396.68
 Standard deviation (SD) 0.50 0.45 1.54 1.55 2.61 3.02
 Precision (% RSD) 2.66 2.36 1.04 1.04 0.66 0.76
 % Accuracy 95.05 96.1 99.14 99.06 99.32 99.17
RLMs matrix
 Mean 19.16 19.27 149.80 150.14 398.55 399.02
 Standard deviation (SD) 0.59 0.47 1.84 1.45 5.36 5.42
 Precision (% RSD) 3.08 2.44 1.23 0.97 1.34 1.36
 % Accuracy 95.80 96.35 99.87 100.09 99.64 99.76
  1. aAverage of twelve determinations of day 1
  2. bAverage of six determinations in three consecutive days