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Table 2 Intra-day and inter-day precision and accuracy of the proposed methods

From: Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

 

LQC (20 ng/mL)

MQC (150 ng/mL)

HQC (400 ng/mL)

Intra-day assaya

Inter-day assayb

Intra-day assay

Inter-day assay

Intra-day assay

Inter-day assay

Human plasma matrix

 Mean

19.01

19.22

148.71

148.59

397.28

396.68

 Standard deviation (SD)

0.50

0.45

1.54

1.55

2.61

3.02

 Precision (% RSD)

2.66

2.36

1.04

1.04

0.66

0.76

 % Accuracy

95.05

96.1

99.14

99.06

99.32

99.17

RLMs matrix

 Mean

19.16

19.27

149.80

150.14

398.55

399.02

 Standard deviation (SD)

0.59

0.47

1.84

1.45

5.36

5.42

 Precision (% RSD)

3.08

2.44

1.23

0.97

1.34

1.36

 % Accuracy

95.80

96.35

99.87

100.09

99.64

99.76

  1. aAverage of twelve determinations of day 1
  2. bAverage of six determinations in three consecutive days