Skip to main content

Table 1 Data of back-calculated VNT concentration of the calibration standards from human plasma and RLMs matrices

From: Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

Nominal concentration (ng/mL)

Human plasma

RLMs

Meana ± SD

Precision (% RSD)

% Accuracy

Meana ± SD

Precision (% RSD)

% Accuracy

5

4.77 ± 0.19

3.89

95.40

4.79 ± 0.17

3.45

95.80

10

9.49 ± 0.25

2.66

94.90

9.54 ± 0.19

2.02

95.40

20

19.36 ± 0.43

2.22

96.80

19.47 ± 0.31

1.61

97.35

30

29.27 ± 0.48

1.63

97.57

29.43 ± 0.59

2.01

98.10

40

41.00 ± 1.26

3.06

102.50

41.22 ± 1.18

2.85

103.05

50

51.05 ± 2.46

4.82

102.10

51.31 ± 2.22

4.32

102.62

80

79.32 ± 1.61

2.03

99.15

79.74 ± 1.21

1.52

99.68

100

100.92 ± 1.32

1.31

100.92

101.46 ± 0.91

0.90

101.46

150

150.78 ± 1.29

0.86

100.52

151.59 ± 0.50

0.33

101.06

300

290.64 ± 3.31

1.14

96.88

292.22 ± 3.99

1.37

97.41

400

400.38 ± 6.40

1.60

100.10

402.51 ± 3.47

0.86

100.63

500

499.05 ± 5.34

1.07

99.81

501.72 ± 1.41

0.28

100.34

  1. aAverage of six determinations