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Table 1 Data of back-calculated VNT concentration of the calibration standards from human plasma and RLMs matrices

From: Liquid chromatography tandem mass spectrometry method for the quantification of vandetanib in human plasma and rat liver microsomes matrices: metabolic stability investigation

Nominal concentration (ng/mL) Human plasma RLMs
Meana ± SD Precision (% RSD) % Accuracy Meana ± SD Precision (% RSD) % Accuracy
5 4.77 ± 0.19 3.89 95.40 4.79 ± 0.17 3.45 95.80
10 9.49 ± 0.25 2.66 94.90 9.54 ± 0.19 2.02 95.40
20 19.36 ± 0.43 2.22 96.80 19.47 ± 0.31 1.61 97.35
30 29.27 ± 0.48 1.63 97.57 29.43 ± 0.59 2.01 98.10
40 41.00 ± 1.26 3.06 102.50 41.22 ± 1.18 2.85 103.05
50 51.05 ± 2.46 4.82 102.10 51.31 ± 2.22 4.32 102.62
80 79.32 ± 1.61 2.03 99.15 79.74 ± 1.21 1.52 99.68
100 100.92 ± 1.32 1.31 100.92 101.46 ± 0.91 0.90 101.46
150 150.78 ± 1.29 0.86 100.52 151.59 ± 0.50 0.33 101.06
300 290.64 ± 3.31 1.14 96.88 292.22 ± 3.99 1.37 97.41
400 400.38 ± 6.40 1.60 100.10 402.51 ± 3.47 0.86 100.63
500 499.05 ± 5.34 1.07 99.81 501.72 ± 1.41 0.28 100.34
  1. aAverage of six determinations
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BMC Chemistry

ISSN: 2661-801X

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