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Table 3 Determination of DRO, CAF, and PCT and PAP in pharmaceutical dosage forms by the proposed methods and results obtained by standard addition technique

From: Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Pharmaceutical dosage form Recovery%a
DRO CAF PCT
D0 RD-Iso IRD DD-RD-DW AAS AAM S1DD RD-Iso IRD AAS AAM S1DD RD-Iso IRD DD-RD-DW
Petro 40(DRO)/400(PCT)/60 (CAF), mean ± SD 99.79 ± 0.48 99.93 ± 0.57 99.91 ± 0.30 99.80 ± 0.49 99.01 ± 0.81 99.90 ± 0.78 99.82 ± 0.65 99.72 ± 0.79 99.83  ± 0.70 100.14 ± 0.21 100.18 ± 0.58 99.63 ± 0.40 100.08 ± 0.45 100.19 ± 0.16 100.05 ± 0.27
Standard addition, mean ± SD 99.63 ± 0.22 99.70 ± 0.35 99.27 ± 0.16 99.57 ± 0.44 101.61 ± 0.97 100.98 ± 0.35 100.32 ± 0.21 99.51 ± 1.80 98.98 ± 1.66 99.96 ± 1.71 99.85 ± 0.05 100.78 ± 1.30 100.84 ± 0.64 100.58 ± 0.59 100.59 ± 0.72
Soumadril Comp. 200 (CAR)/160 (PCT)/32 (CAF), mean ± SD   100.76 ± 0.49 100.02 ± 0.51 100.01 ± 0.51 99.86 ± 0.46 100.01 ± 0.41 100.20 ± 0.62 99.52 ± 0.43 100.58 ± 0.61 101.03 ± 0.53 100.85 ± 0.47 100.75 ± 0.62
Standard addition, mean ± SD   101.08 ± 0.76 101.23 ± 0.43 100.88 ± 0.59 99.63 ± 0.85 99.57 ± 1.21 100.48 ± 1.35 99.30 ± 0.32 100.64 ± 0.60 100.77 ± 0.55 100. 81 ± 0.68 100.47 ± 0.85
Panadol Extra 500 (PCT)/65 (CAF), mean ± SD   100.55 ± 0.36 100.05 ± 0.39 99.76 ± 0.78 99.68 ± 0.73 100.08 ± 0.31 100.14 ± 0.58 100.01 ± 0.82 100.22 ± 0.30 100.27 ± 0.28 100.32 ± 0.71 100.54 ± 0.25
Standard addition, mean ± SD   100.38 ± 0.55 100.79 ± 0.84 100.54 ± 0.57 99.88 ± 0.47 100.17 ± 1.35 100.24 ± 0.82 99.57 ± 0.54 99.86 ± 0.57 100.34 ± 0.68 100. 08 ± 0.78 100.29 ± 0.61
  1. aAverage of three determinations