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Table 3 Determination of DRO, CAF, and PCT and PAP in pharmaceutical dosage forms by the proposed methods and results obtained by standard addition technique

From: Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Pharmaceutical dosage form

Recovery%a

DRO

CAF

PCT

D0

RD-Iso

IRD

DD-RD-DW

AAS

AAM

S1DD

RD-Iso

IRD

AAS

AAM

S1DD

RD-Iso

IRD

DD-RD-DW

Petro 40(DRO)/400(PCT)/60 (CAF), mean ± SD

99.79 ± 0.48

99.93 ± 0.57

99.91 ± 0.30

99.80 ± 0.49

99.01 ± 0.81

99.90 ± 0.78

99.82 ± 0.65

99.72 ± 0.79

99.83  ± 0.70

100.14 ± 0.21

100.18 ± 0.58

99.63 ± 0.40

100.08 ± 0.45

100.19 ± 0.16

100.05 ± 0.27

Standard addition, mean ± SD

99.63 ± 0.22

99.70 ± 0.35

99.27 ± 0.16

99.57 ± 0.44

101.61 ± 0.97

100.98 ± 0.35

100.32 ± 0.21

99.51 ± 1.80

98.98 ± 1.66

99.96 ± 1.71

99.85 ± 0.05

100.78 ± 1.30

100.84 ± 0.64

100.58 ± 0.59

100.59 ± 0.72

Soumadril Comp. 200 (CAR)/160 (PCT)/32 (CAF), mean ± SD

 

100.76 ± 0.49

100.02 ± 0.51

100.01 ± 0.51

99.86 ± 0.46

100.01 ± 0.41

100.20 ± 0.62

99.52 ± 0.43

100.58 ± 0.61

101.03 ± 0.53

100.85 ± 0.47

100.75 ± 0.62

Standard addition, mean ± SD

 

101.08 ± 0.76

101.23 ± 0.43

100.88 ± 0.59

99.63 ± 0.85

99.57 ± 1.21

100.48 ± 1.35

99.30 ± 0.32

100.64 ± 0.60

100.77 ± 0.55

100. 81 ± 0.68

100.47 ± 0.85

Panadol Extra 500 (PCT)/65 (CAF), mean ± SD

 

100.55 ± 0.36

100.05 ± 0.39

99.76 ± 0.78

99.68 ± 0.73

100.08 ± 0.31

100.14 ± 0.58

100.01 ± 0.82

100.22 ± 0.30

100.27 ± 0.28

100.32 ± 0.71

100.54 ± 0.25

Standard addition, mean ± SD

 

100.38 ± 0.55

100.79 ± 0.84

100.54 ± 0.57

99.88 ± 0.47

100.17 ± 1.35

100.24 ± 0.82

99.57 ± 0.54

99.86 ± 0.57

100.34 ± 0.68

100. 08 ± 0.78

100.29 ± 0.61

  1. aAverage of three determinations