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Table 2 Determination of DRO, CAF, and PCT and PAP in laboratory prepared mixtures and pharmaceutical dosage forms by the proposed methods and results obtained by standard addition technique

From: Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Concentration (µg/mL) Recovery%a
Lab prepared mix. DRO CAF
DRO CAF PCT PAP D0 RD-Iso IRD DD-RD-DW AAS AAM S1DD RD-Iso IRD
2b 3 20 2 101.24 98.78 100.95 101.25 99.46 100.35 100.27 100.22 100.27
10 10 10 1 98.24 99.75 99.33 98.24 99.65 100.17 99.98 99.97 99.98
6 12 6 6 99.42 99.41 99.87 99.42 99.94 100.43 100.23 100.22 100.24
20 8 4 4 100.13 100.05 99.96 100.14 99.62 100.18 100.00 99.98 100.01
12 20 8 2 99.83 99.82 99.84 99.84 99.78 100.22 100.00 100.01 100.00
0c 2 10 1      99.97 99.97 100.19 101.20 100.15
0d 2.6 20 2      100.07 99.89 100.21 99.67 100.20
Mean ± SD 99.77 ± 1.09 99.56 ± 0.49 99.99 ± 0.53 99.78 ± 1.09 99.78 ± 0.21 100.17 ± 0.19 100.12 ±0.12 100.20 ± 0.52 100.12 ± 0.12
Concentration (µg/mL) Recovery%a
Lab prepared mix. PCT PAP
DRO CAF PCT PAP AAS AAM S1DD RD-Iso IRD DD-RD-DW D1 DD-RD-DW
2b 3 20 2 100.11 101.21 99.80 100.21 100.12 100.12 99.20 99.85
10 10 10 1 100.07 100.65 100.02 100.26 100.07 100.08 98.66 99.61
6 12 6 6 100.33 100.92 100.59 100.65 100.34 100.34 102.38 100.68
20 8 4 4 99.84 100.37 100.25 100.39 99.94 99.94 98.80 98.80
12 20 8 2 100.18 99.98 100.46 100.35 100.12 100.12 99.65 98.00
0c 2 10 1 100.21 100.89 100.45 99.65 100.31 99.89 99.42 99.38
0d 2.6 20 2 99.95 99.91 99.97 99.82 99.76 100.32 98.02 100.75
Mean ± SD 100.10 ± 0.16 100.56 ± 0.49 100.22 ± 0.29 100.19 ± 0.34 100.09 ± 0.20 100.11 ± 0.17 99.45 ± 1.40 99.57 ± 0.99
  1. aAverage of three determinations
  2. bThe ratio of the lab mixture in Petro tablets
  3. cThe ratio of the lab mixture of (CAF:PCT) in Soumadril Compound tablets
  4. dThe ratio of the lab mixture of (CAF:PCT) in Panadol Extra tablets