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Table 4 Docking scores and amino acid interactions of the docked compounds on the active site of mitogen activated kinase (MK-2)

From: Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking

Compounds

(S) Kcal/mol

Amino acid

Interacting group

Type of interaction

H-bond length (Å)

3c

−18.8805

Asp 207

NH

H bond (donor)

1.25

4a

−20.8063

Leu 141

Asp 207

SO2

NH

H bond (acceptor)

H bond (donor)

2.96

2.22

4b

−16.2293

Asp 207

NH

H bond (donor)

2.12

4c

−22.9000

Asp 207

NH

H bond (donor)

1.53