Compds | Inhibition rates against different cells (%)a | IC50 (μM)b | |||||
---|---|---|---|---|---|---|---|
MGC-803 | PC3 | Bcap-37 | NIH3T3 | MGC-803 | PC3 | Bcap-37 | |
5a | 71.9 ± 0.9 | 68.5 ± 2.3 | 44.1 ± 2.6 | 65.7 ± 1.3 | 7.69 ± 0.37 | 9.24 ± 0.46 | 11.71 ± 0.39 |
5b | 83.5 ± 1.5 | 78.7 ± 2.4 | 57.3 ± 2.0 | 15.4 ± 1.5 | 5.20 ± 0.51 | 8.12 ± 0.46 | 10.05 ± 0.67 |
5c | 79.2 ± 2.8 | 76.5 ± 1.7 | 54.2 ± 1.1 | 16.1 ± 2.7 | 5.44 ± 0.45 | 7.85 ± 0.32 | 9.34 ± 0.52 |
5d | 87.5 ± 0.2 | 86.3 ± 0.8 | 58.5 ± 1.3 | 71.9 ± 1.4 | 1.72 ± 0.22 | 2.68 ± 0.43 | 7.52 ± 0.36 |
5e | 87.0 ± 1.0 | 75.2 ± 7.8 | 67.3 ± 3.9 | 53.8 ± 1.8 | 1.89 ± 0.26 | 4.71 ± 0.36 | 9.6 ± 0.42 |
5f | 90.7 ± 0.6 | 93.0 ± 1.8 | 76.5 ± 1.9 | 21.5 ± 2.7 | 0.85 ± 0.43 | 1.37 ± 0.22 | 4.98 ± 0.39 |
5g | 85.9 ± 1.2 | 83.1 ± 2.8 | 74.9 ± 2.0 | 74.3 ± 0.9 | 2.02 ± 0.37 | 2.18 ± 0.31 | 5.61 ± 0.50 |
5h | 62.3 ± 1.4 | 43.7 ± 12.1 | 36.6 ± 2.7 | 13.4 ± 2.2 | 9.06 ± 0.40 | 11.68 ± 0.48 | 15.64 ± 0.51 |
5i | 79.4 ± 2.4 | 65.1 ± 2.6 | 47.1 ± 2.6 | 14.4 ± 2.6 | 7.78 ± 0.48 | 9.36 ± 0.52 | 10.73 ± 0.62 |
5j | 76.3 ± 0.8 | 71.9 ± 3.1 | 45.4 ± 2.2 | 41.0 ± 2.1 | 6.42 ± 0.44 | 8.64 ± 0.47 | 12.11 ± 0.31 |
5k | 82.1 ± 3.0 | 76.3 ± 2.5 | 60.2 ± 1.4 | 3.0 ± 2.3 | 2.94 ± 0.32 | 8.12 ± 0.46 | 8.92 ± 0.58 |
5l | 61.2 ± 1.3 | 55.7 ± 1.5 | 54.6 ± 1.0 | 0.8 ± 1.6 | 4.33 ± 0.35 | 9.08 ± 0.52 | 9.83 ± 0.46 |
5m | 81.1 ± 1.7 | 81.2 ± 2.8 | 66.4 ± 1.5 | 12.4 ± 2.5 | 2.05 ± 0.39 | 3.79 ± 0.47 | 7.82 ± 0.39 |
5n | 78.7 ± 2.7 | 69.0 ± 1.7 | 55.8 ± 1.1 | 29.6 ± 2.4 | 3.33 ± 0.42 | 4.16 ± 0.43 | 8.70 ± 0.54 |
ADMc | 97.5 ± 1.2 | 91.2 ± 0.4 | 94.5 ± 0.9 | 100.0 ± 0.7 | 0.74 ± 0.24 | 1.01 ± 0.20 | 1.90 ± 0.25 |