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Table 1 The structures of ligustrazine derivatives VA-01VA-20

From: Synthesis and protective effect of new ligustrazine-vanillic acid derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells

Compound

R

Yield (%)

VA-01

CH3O–

52.5

VA-02

OH–

98.1

VA-03

CH3CH2NH–

89.5

VA-04

65.2

VA-05

CH3NH–

87.0

VA-06

74.0

VA-07

68.9

VA-08

76.4

VA-09

86.7

VA-10

79.3

VA-11

68.3

VA-12

57.6

VA-13

65.7

VA-14

57.8

VA-15

68.9

VA-16

67.0

VA-17

65.2

VA-18

62.7

VA-19

75.1

VA-20

83.2