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Table 5 Anticancer activity of the selected synthesized analogous

From: Design, synthesis and biological potentials of novel tetrahydroimidazo[1,2-a]pyrimidine derivatives

MCF-7 µMolar drug concentrations
LC50 TGI GI a50
1 >100 >100 82.82
3 >100 >100 75.3
10 NE NE NE
13 >100 >100 54
15 >100 >100 97.9
18 >100 >100 66.8
20 >100 >100 80.08
22 >100 >100 94.5
23 >100 73.05 34.78
MNP >100 >100 >100
ADR 18.01 <0.1 <0.1
  1. Where aGI50 ≤ µMolar is considered to be active, LC50, concentration of drug causing 50% cell kill; GI50, concentration of drug causing 50% inhibition of cell growth; TGI, concentration of drug causing total inhibition of cell growth; ADR adriamycin, positive control compound