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Table 4 Percentage (%) control growth against human breast cancer cell line MCF-7

From: Design, synthesis and biological potentials of novel tetrahydroimidazo[1,2-a]pyrimidine derivatives

  Human breast cancer cell line MCF-7
% Control growth
Molar drug concentrations
Experiment 1 Experiment 2 Experiment 3 Average values
10−7M 10−6M 10−5M 10−4M 10−7M 10−6M 10−5M 10−4M 10−7M 10−6M 10−5M 10−4M 10−7M 10−6M 10−5M 10−4M
1 106.9 101.9 100.7 38.0 106.9 97.2 90.7 38.6 102.8 106.8 92.6 41.0 105.6 102.0 94.7 39.2
3 111.3 91.2 83.4 29.3 107.9 101.8 90.2 33.2 90.1 110.2 96.3 38.6 103.1 101.1 90.0 33.7
10 111.2 106.9 87.6 80.0 45.3 115.4 88.8 93.4 74.4 106.6 108.4 113.4 77.0 109.6 94.9 95.6
13 101.0 104.4 84.4 −1.9 107.3 107.7 92.6 1.9 102.5 105.9 91.9 16.8 103.6 106.0 89.6 5.6
15 96.6 100.8 99.0 41.7 106.8 114.1 102.6 49.0 110.1 117.3 107.4 55.3 104.5 110.8 103.0 48.7
18 94.69 99.7 92.55 22.66 117.9 108.6 92.21 22.27 107 113.6 105 21.09 106.5 107.3 96.59 22.01
20 110.7 96.6 78.2 34.8 114.2 112.1 87.7 35.3 107.7 108.6 99.0 42.1 110.9 105.8 88.3 37.4
22 102.1 107.3 91.5 46.9 99.6 103.7 91.1 48.3 104.0 111.1 104.4 46.1 101.9 107.4 95.7 47.1
23 100.2 95.4 77.2 44.5 104.0 101.5 76.8 43.1 76.3 101.6 81.4 17.1 93.5 99.5 78.5 34.9
MNP 105.0 97.0 99.8 86.2 101.6 108.5 90.4 89.1 102.4 64.1 90.4 81.0 103.0 89.9 93.5 85.5
ADR −34.5 −46.5 −63.5 −79.5 −62 −49.7 −67 −79.3 13.69 −38.2 −63.6 −69.9 −27.6 −44.8 −64.7 −76.2
  1. The significance of italic values was found to be most active against human breast (MCF-7) cancer cell line due to the presence of electron withdrawing groups (o-Cl) on benzylidene portion