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Table 4 Percentage (%) control growth against human breast cancer cell line MCF-7

From: Design, synthesis and biological potentials of novel tetrahydroimidazo[1,2-a]pyrimidine derivatives

 

Human breast cancer cell line MCF-7

% Control growth

Molar drug concentrations

Experiment 1

Experiment 2

Experiment 3

Average values

10−7M

10−6M

10−5M

10−4M

10−7M

10−6M

10−5M

10−4M

10−7M

10−6M

10−5M

10−4M

10−7M

10−6M

10−5M

10−4M

1

106.9

101.9

100.7

38.0

106.9

97.2

90.7

38.6

102.8

106.8

92.6

41.0

105.6

102.0

94.7

39.2

3

111.3

91.2

83.4

29.3

107.9

101.8

90.2

33.2

90.1

110.2

96.3

38.6

103.1

101.1

90.0

33.7

10

111.2

106.9

87.6

80.0

45.3

115.4

88.8

93.4

74.4

106.6

108.4

113.4

77.0

109.6

94.9

95.6

13

101.0

104.4

84.4

−1.9

107.3

107.7

92.6

1.9

102.5

105.9

91.9

16.8

103.6

106.0

89.6

5.6

15

96.6

100.8

99.0

41.7

106.8

114.1

102.6

49.0

110.1

117.3

107.4

55.3

104.5

110.8

103.0

48.7

18

94.69

99.7

92.55

22.66

117.9

108.6

92.21

22.27

107

113.6

105

21.09

106.5

107.3

96.59

22.01

20

110.7

96.6

78.2

34.8

114.2

112.1

87.7

35.3

107.7

108.6

99.0

42.1

110.9

105.8

88.3

37.4

22

102.1

107.3

91.5

46.9

99.6

103.7

91.1

48.3

104.0

111.1

104.4

46.1

101.9

107.4

95.7

47.1

23

100.2

95.4

77.2

44.5

104.0

101.5

76.8

43.1

76.3

101.6

81.4

17.1

93.5

99.5

78.5

34.9

MNP

105.0

97.0

99.8

86.2

101.6

108.5

90.4

89.1

102.4

64.1

90.4

81.0

103.0

89.9

93.5

85.5

ADR

−34.5

−46.5

−63.5

−79.5

−62

−49.7

−67

−79.3

13.69

−38.2

−63.6

−69.9

−27.6

−44.8

−64.7

−76.2

  1. The significance of italic values was found to be most active against human breast (MCF-7) cancer cell line due to the presence of electron withdrawing groups (o-Cl) on benzylidene portion