Table 1 System suitability parameters for the determination of paritaprevir (PAR), dasabuvir (DAS), ritonavir (RIT), and ombitasvir (OMB) using the proposed HPLC method
Analyte | Retention time (min) (Rt) | Capacity factor (k) | Selectivity (α) | Resolution (Rs) | Tailing (Tf) | Efficiency (no. of theoretical plates) |
|---|---|---|---|---|---|---|
PAR | 1.476 | 1.73 | – | – | 1 | 2443 |
DAS | 2.835 | 4.13 | 2.39 | 10.62 | 1.20 | 8211 |
RIT | 3.499 | 5.33 | 1.29 | 4.25 | 1 | 5555 |
SOR | 4.720 | 7.53 | 1.41 | 6.49 | 1.20 | 10,085 |
OMB | 6.388 | 10.53 | 1.40 | 6.64 | 1.20 | 6632 |