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Table 5 Assay results for the determination of the studied analytes in their different dosage forms by the proposed and official method [41]

From: Rapid micellar HPLC analysis of loratadine and its major metabolite desloratadine in nano-concentration range using monolithic column and fluorometric detection: application to pharmaceuticals and biological fluids

Dosage form

Proposed method

Official method [41]

Amount taken (ng/mL)

Amount found (ng/mL)

% recoverya

Amount taken (µg/mL)

Amount found (µg/mL)

% recoverya

Loratadine 10 mg

Tablet

50.0

51.636

103.27

5.0

4.950

98.99

100.0

97.556

97.56

30.0

30.150

100.5

200.0

200.800

100.41

50.0

49.610

99.22

Mean %

  

100.41

  

99.57

±SD

  

2.86

  

0.81

t testb

0.492 (2.776)

F testb

12.315 (19)

Desa 5 mg

Tablet

50.0

50.391

100.78

5.0

4.980

99.67

100.0

99.366

99.37

30.0

30.360

101.2

200.0

200.100

100.07

50.0

49.390

98.78

Mean %

  

100.07

  

99.88

±SD

  

0.71

  

1.22

t testb

0.233 (2.776)

F testb

3.014 (19)

  1. aEach result is the average of three separate determinations
  2. bThe values between parentheses are the tabulated t and F values at P = 0.05