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Table 3 Anti-proliferative effects of glycyrrhetinic acid hybrids

From: Design, synthesis, and biological evaluation of the novel glycyrrhetinic acid-cinnamoyl hybrids as anti-tumor agents

Compound IC50 (μM)a
Hela HepG2 HT-29 MDCK HY926 H9C2
1a 23.67 ± 2.98 24.40 ± 1.39 22.34 ± 1.75 22.63 ± 1.38 28.93 ± 1.85 46.13 ± 2.01
2a 14.19 ± 1.10 22.08 ± 1.18 21.72 ± 1.81 37.95 ± 1.81 27.63 ± 1.84 >50
3a 24.56 ± 1.72 31.99 ± 1.90 22.16 ± 2.34 22.93 ± 2.43 >50 >50
4a 17.53 ± 1.52 12.67 ± 1.10 14.88 ± 1.80 22.24 ± 2.56 31.01 ± 1.87 >50
5a 23.38 ± 1.38 31.15 ± 1.34 32.99 ± 1.92 21.67 ± 1.01 >50 36.14 ± 1.92
6a 22.48 ± 2.08 24.36 ± 1.44 24.39 ± 1.76 33.67 ± 1.40 24.99 ± 1.38 >50
7a 28.01 ± 1.63 25.41 ± 1.97 26.41 ± 1.96 >50 45.07 ± 2.25 >50
8a 8.54 ± 1.44 21.47 ± 1.50 15.02 ± 1.26 31.84 ± 2.79 27.73 ± 1.39 >50
9a 30.67 ± 1.89 21.88 ± 1.41 25.52 ± 1.29 27.72 ± 1.08 30.79 ± 1.37 47.43 ± 1.07
1b 26.92 ± 1.74 32.29 ± 1.00 28.63 ± 2.99 33.33 ± 2.98 33.65 ± 3.09 >50
2b 23.13 ± 2.33 33.08 ± 2.09 29.34 ± 2.22 41.30 ± 1.48 >50 45.75 ± 1.80
3b 22.54 ± 2.16 27.31 ± 1.95 26.21 ± 1.24 >30 38.46 ± 2.02 >50
4b 28.69 ± 1.68 22.38 ± 1.29 22.35 ± 1.2 >30 >50 >50
GA >50 >50 >50 >100 >100 >100
DPP 3.76 ± 0.38 4.57 ± 0.85 5.28 ± 0.74 9.97 ± 1.12 5.12 ± 0.71 5.31 ± 0.26
  1. aIC50 values were calculated using GraphPad Prism 5.01. Data were shown as mean ± SD (n = 3) from three independent experiments