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Table 3 Anti-proliferative effects of glycyrrhetinic acid hybrids

From: Design, synthesis, and biological evaluation of the novel glycyrrhetinic acid-cinnamoyl hybrids as anti-tumor agents

Compound

IC50 (μM)a

Hela

HepG2

HT-29

MDCK

HY926

H9C2

1a

23.67 ± 2.98

24.40 ± 1.39

22.34 ± 1.75

22.63 ± 1.38

28.93 ± 1.85

46.13 ± 2.01

2a

14.19 ± 1.10

22.08 ± 1.18

21.72 ± 1.81

37.95 ± 1.81

27.63 ± 1.84

>50

3a

24.56 ± 1.72

31.99 ± 1.90

22.16 ± 2.34

22.93 ± 2.43

>50

>50

4a

17.53 ± 1.52

12.67 ± 1.10

14.88 ± 1.80

22.24 ± 2.56

31.01 ± 1.87

>50

5a

23.38 ± 1.38

31.15 ± 1.34

32.99 ± 1.92

21.67 ± 1.01

>50

36.14 ± 1.92

6a

22.48 ± 2.08

24.36 ± 1.44

24.39 ± 1.76

33.67 ± 1.40

24.99 ± 1.38

>50

7a

28.01 ± 1.63

25.41 ± 1.97

26.41 ± 1.96

>50

45.07 ± 2.25

>50

8a

8.54 ± 1.44

21.47 ± 1.50

15.02 ± 1.26

31.84 ± 2.79

27.73 ± 1.39

>50

9a

30.67 ± 1.89

21.88 ± 1.41

25.52 ± 1.29

27.72 ± 1.08

30.79 ± 1.37

47.43 ± 1.07

1b

26.92 ± 1.74

32.29 ± 1.00

28.63 ± 2.99

33.33 ± 2.98

33.65 ± 3.09

>50

2b

23.13 ± 2.33

33.08 ± 2.09

29.34 ± 2.22

41.30 ± 1.48

>50

45.75 ± 1.80

3b

22.54 ± 2.16

27.31 ± 1.95

26.21 ± 1.24

>30

38.46 ± 2.02

>50

4b

28.69 ± 1.68

22.38 ± 1.29

22.35 ± 1.2

>30

>50

>50

GA

>50

>50

>50

>100

>100

>100

DPP

3.76 ± 0.38

4.57 ± 0.85

5.28 ± 0.74

9.97 ± 1.12

5.12 ± 0.71

5.31 ± 0.26

  1. aIC50 values were calculated using GraphPad Prism 5.01. Data were shown as mean ± SD (n = 3) from three independent experiments
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BMC Chemistry

ISSN: 2661-801X

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