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Table 1 Evaluation of 4a–4e against different tumor cell lines

From: Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity

Compounds

IC50 (μM)a

Hep-G2

A549

BGC-823

MCF-7

PC-3

4a

7.83 ± 0.69

4.01 ± 0.37

<0.1

<0.1

NIb

4b

2.81 ± 0.22

15.5 ± 1.34

<0.1

6.53 ± 0.35

NI

4c

5.24 ± 0.05

3.01 ± 0.28

0.22 ± 0.02

6.99 ± 0.57

0.28 ± 0.05

4d

8.49 ± 0.68

0.27 ± 0.03

0.11 ± 0.01

3.51 ± 0.22

10.61 ± 1.13

4e

4.19 ± 0.35

8.76 ± 0.07

< 0.1

5.26 ± 0.41

2.51 ± 0.05

1

15.90 ± 1.13

16.29 ± 1.36

23.74 ± 1.53

12.60 ± 1.09

72.74 ± 6.88

5-FU

55.74 ± 5.09

22.62 ± 2.19

8.82 ± 0.78

21.47 ± 1.99

12.23 ± 1.18

  1. aIC50 values are presented as the mean ± SD (standard deviation) from three separated experiments
  2. bNo inhibition detected
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BMC Chemistry

ISSN: 2661-801X

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