Skip to main content

Table 1 Evaluation of 4a4e against different tumor cell lines

From: Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity

Compounds IC50 (μM)a
Hep-G2 A549 BGC-823 MCF-7 PC-3
4a 7.83 ± 0.69 4.01 ± 0.37 <0.1 <0.1 NIb
4b 2.81 ± 0.22 15.5 ± 1.34 <0.1 6.53 ± 0.35 NI
4c 5.24 ± 0.05 3.01 ± 0.28 0.22 ± 0.02 6.99 ± 0.57 0.28 ± 0.05
4d 8.49 ± 0.68 0.27 ± 0.03 0.11 ± 0.01 3.51 ± 0.22 10.61 ± 1.13
4e 4.19 ± 0.35 8.76 ± 0.07 < 0.1 5.26 ± 0.41 2.51 ± 0.05
1 15.90 ± 1.13 16.29 ± 1.36 23.74 ± 1.53 12.60 ± 1.09 72.74 ± 6.88
5-FU 55.74 ± 5.09 22.62 ± 2.19 8.82 ± 0.78 21.47 ± 1.99 12.23 ± 1.18
  1. aIC50 values are presented as the mean ± SD (standard deviation) from three separated experiments
  2. bNo inhibition detected