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Table 5 Pharmacokinetic parameters of bergapten after oral administration of 5, 10, 15 mg kg−1 (n = 8, mean ± SD)

From: The pharmacokinetics, bioavailability and excretion of bergapten after oral and intravenous administration in rats using high performance liquid chromatography with fluorescence detection

Parameters Low (5 mg kg−1) Medium (10 mg kg−1) High (15 mg kg−1)
Tmax (h) 3.20 ± 0.45 3.88 ± 0.99 4.56 ± 1.40
Cmax (ng mL−1) 859.4 ± 253.6 1397 ± 573 1307 ± 617
AUC (0–tn) (ng mL−1 h−1) 3517 ± 1299 8255 ± 3536 9197 ± 5790
AUC(0–∞) (ng mL−1 h−1) 3537 ± 1302 8266 ± 3534 9306 ± 5782
V/F (L) 0.0107 ± 0.0044 0.0115 ± 0.0139 0.0124 ± 0.0138
T1/2α (h) 9.35 ± 3.07 12.88 ± 12.21 14.35 ± 15.75
MRT(0–tn) (h) 3.72 ± 0.53 4.83 ± 0.47 5.57 ± 1.15
MRT(0–∞) (h) 3.91 ± 0.51 4.87 ± 0.47 6.65 ± 2.27