Table 2 DTT structures from initial SAR study and corresponding Hammett sigma constants [26, 31]
R1 (σp) | R2 (σp) | Entry |
|---|---|---|
4-OMe-C6H4 (−0.08) | H (0) | 4d |
C6H5 (−0.01) | H (0) | 4e |
CH2CF3 (0.09) | H (0) | 4f |
4-Cl-C6H4 (0.12) | H (0) | 4g |
H (0) | Ethyl (−0.15) | 5e |
H (0) | Cyclopropyl (−0.21) | 5f |
H (0) | 4-Cl-C6H4 (0.12) | 5g |
H (0) | 4-OMe-C6H4 (−0.08) | ADT |