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Table 2 DTT structures from initial SAR study and corresponding Hammett sigma constants [26, 31]

From: Further structure–activity relationships study of substituted dithiolethiones as glutathione-inducing neuroprotective agents

R1p) R2p) Entry
4-OMe-C6H4 (−0.08) H (0) 4d
C6H5 (−0.01) H (0) 4e
CH2CF3 (0.09) H (0) 4f
4-Cl-C6H4 (0.12) H (0) 4g
H (0) Ethyl (−0.15) 5e
H (0) Cyclopropyl (−0.21) 5f
H (0) 4-Cl-C6H4 (0.12) 5g
H (0) 4-OMe-C6H4 (−0.08) ADT