Scheme 1From: 4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studiesReagents: a Substituted benzyl halide, EtOH, H2O, NaOAc reflux; b LiBH4, THF, reflux; c 3-bromobenzylamine hydrochloride, LiBH4, THF, HOAc, refluxBack to article page