Table 3 α-Glucosidase inhibitory activity of the isolated compounds
From: α-Glucosidase inhibitors from the bark of Mangifera mekongensis
Compounds | Inhibition (I %) | IC50 (µM) | ||||
|---|---|---|---|---|---|---|
250 (µM) | 100 (µM) | 50 (µM) | 25 (µM) | 10 (µM) | ||
1 | * | 91.8 ± 1.1 | 67.7 ± 1.4 | 38.6 ± 1.2 | 24.4 ± 1.8 | 27.7 |
3 | – | – | – | – | – | >250 |
4 | – | – | – | – | – | >250 |
5 | * | 90.9 ± 1.4 | 75.9 ± 2.6 | 49.7 ± 3.1 | 32.1 ± 2.3 | 21.1 |
6 | * | 95.2 ± 2.3 | 85.6 ± 1.0 | 70.8 ± 1.2 | 39.0 ± 1.8 | 13.2 |
7 | * | 88.5 ± 1.0 | 75.7 ± 1.2 | 68.0 ± 1.1 | 32.9 ± 1.6 | 16.7 |
9 | 95.9 ± 1.0 | 32.2 ± 1.0 | 15.9 ± 1.1 | – | – | 112.0 |
Acarbosea | 59.8 ± 1.2 | 21.2 ± 2.2 | 9.8 ± 1.1 | 3.2 ± 1.7 | – | 214.5 |
Compounds | Inhibition (I %) | IC50 (µM) | ||||
|---|---|---|---|---|---|---|
25 (µM) | 10 (µM) | 5.0 (µM) | 2.5 (µM) | 1.0 (µM) | ||
2 | * | 93.1 ± 1.2 | 82.6 ± 1.4 | 50.8 ± 1.1 | 15.2 ± 1.2 | 2.5 |
8 | * | 87.5 ± 1.0 | 78.4 ± 1.6 | 62.5 ± 1.1 | 46.5 ± 1.1 | 1.2 |