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Table 3 Application of the proposed approaches for the determination of adapalene in pure form

From: Determination of adapalene in gel formulation by conventional and derivative synchronous fluorimetric approaches. Application to stability studies and in vitro diffusion test

Parameter

Amount taken (ng/mL)

First approach at 389 nm

Second approach

Comparison method [3]

Amount found (ng/mL)

% found

Amount found (ng/mL)

% found

Amount found (µg/mL)

% found

SDSF at 346 nm

FDSF at 312.45 nm

SDSF at 346 nm

FDSF at 312.45 nm

ADP

2.0

2.00

100.00

1.991

1.992

99.54

99.62

20.0

99.22

4.0

4.008

100.20

4.001

3.977

100.02

99.43

30.0

99.88

6.0

5.988

99.80

5.976

5.962

99.59

99.36

40.0

101.15

8.0

8.053

100.66

8.134

8.000

101.68

100.00

  

10.0

9.948

99.48

9.915

10.146

99.15

101.46

  

12.0

11.956

99.63

11.918

12.023

99.31

100.19

  

14.0

14.049

100.35

14.066

13.900

100.47

99.29

  

Mean

  

100.02

  

99.97

99.91

 

100.08

SD

  

0.42

  

0.88

0.76

 

0.98

t

  

1.06 (2.31)*

  

0.73 (2.31)

0.93 (2.31)

  

F

  

2.88 (5.14)*

  

1.53 (19.33)

1.16 (19.33)

  
  1. N.B. Each result is the average of three separate determinations
  2. * The values between parentheses are the tabulated t and F values at P = 0.05 [15]