Table 2 Analysis of variance for central composite design and tests of the regression coefficients and intercepts of coded equations for curdione, furanodienone, curcumol and germacrone
Source | Mean squares | F | p value | Coefficient estimate | |
|---|---|---|---|---|---|
Curdione | Model | 0.075 | 12.99 | 0.0014 | |
Intercept | 1.790 | ||||
X 1 | 0.360 | 61.88 | 0.0001 | 0.160 | |
X 2 | 0.120 | 20.88 | 0.0026 | 0.094 | |
X 3 | 0.042 | 7.29 | 0.0307 | 0.056 | |
X 1 X 2 | 0.029 | 5.04 | 0.0596 | −0.060 | |
X 1 X 3 | 1.326 × 10−3 | 0.23 | 0.6466 | −0.013 | |
X 2 X 3 | 8.001 × 10−3 | 1.38 | 0.2779 | 0.032 | |
X 2 1 | 4.588 × 10−3 | 0.79 | 0.4027 | −0.020 | |
X 2 2 | 0.110 | 19.80 | 0.0030 | −0.100 | |
X 2 3 | 3.531 × 10−3 | 0.61 | 0.4601 | −0.018 | |
Lack of Fit | 6.474 × 10−3 | 1.60 | 0.4281 | ||
R 2 = 0.9435, Q 2 = 0.8677, Adeq Precision = 12.121 | |||||
Furanodienone | Model | 0.098 | 27.14 | 0.0001 | |
Intercept | 1.370 | ||||
X 1 | 0.330 | 90.16 | <0.0001 | 0.150 | |
X 2 | 0.190 | 51.54 | 0.0002 | 0.120 | |
X 3 | 0.110 | 29.00 | 0.0010 | 0.088 | |
X 1 X 2 | 9.730 × 10−3 | 2.69 | 0.1452 | −0.035 | |
X 1 X 3 | 1.966 × 10−3 | 0.54 | 0.4852 | −0.013 | |
X 2 X 3 | 1.566 × 10−4 | 0.04 | 0.8412 | 4.425 × 10−3 | |
X 2 1 | 0.025 | 7.01 | 0.0331 | −0.047 | |
X 2 2 | 0.250 | 70.00 | <0.0001 | −0.150 | |
X 2 3 | 0.015 | 4.14 | 0.0813 | −0.036 | |
Lack of Fit | 3.853 × 10−3 | 1.27 | 0.4963 | ||
R 2 = 0.9721, Q 2 = 0.9117, Adeq Precision = 16.176 | |||||
Curcumol | Model | 2.694 × 10−3 | 15.43 | 0.0008 | |
Intercept | 0.210 | ||||
X 1 | 8.931 × 10−3 | 51.15 | 0.0002 | 0.026 | |
X 2 | 4.953 × 10−3 | 28.37 | 0.0011 | 0.019 | |
X 3 | 2.519 × 10−3 | 14.43 | 0.0067 | 0.014 | |
X 1 X 2 | 1.739 × 10−4 | 1.00 | 0.3515 | −4.663 × 10−3 | |
X 1 X 3 | 9.453 × 10−5 | 0.54 | 0.4858 | 3.437 × 10−3 | |
X 2 X 3 | 9.045 × 10−5 | 0.52 | 0.4950 | 3.362 × 10−3 | |
X 2 1 | 3.674 × 10−7 | 2.10 × 10−3 | 0.9647 | −1.805 × 10−4 | |
X 2 2 | 6.848 × 10−3 | 39.22 | 0.0004 | −0.025 | |
X 2 3 | 2.553 × 10−4 | 1.46 | 0.2658 | −4.759 × 10−3 | |
Lack of Fit | 2.209 × 10−4 | 3.76 | 0.2232 | ||
R 2 = 0.9520, Q 2 = 0.8957, Adeq Precision = 14.233 | |||||
Germacrone | Model | 7.756 × 10−3 | 16.36 | 0.0007 | |
Intercept | 0.350 | ||||
X 1 | 0.023 | 49.39 | 0.0002 | 0.041 | |
X 2 | 0.010 | 21.15 | 0.0025 | 0.027 | |
X 3 | 9.435 × 10−3 | 19.90 | 0.0029 | 0.026 | |
X 1 X 2 | 8.694 × 10−4 | 1.83 | 0.2178 | −0.010 | |
X 1 X 3 | 9.940 × 10−5 | 0.21 | 0.6609 | 3.525 × 10−3 | |
X 2 X 3 | 1.682 × 10−5 | 0.04 | 0.8559 | 1.450 × 10−3 | |
X 2 1 | 7.945 × 10−4 | 1.68 | 0.2365 | −8.395 × 10−3 | |
X 2 2 | 0.025 | 52.89 | 0.0002 | −0.047 | |
X 2 3 | 4.873 × 10−4 | 1.03 | 0.3444 | −6.574 × 10−3 | |
Lack of Fit | 6.264 × 10−4 | 6.72 | 0.1346 | ||
R 2 = 0.9546, Q 2 = 0.9076, Adeq Precision = 13.465 | |||||