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Table 2 Surface tension at the surface-to-air interface for nasal OTC formulations

From: Surface tension examination of various liquid oral, nasal, and ophthalmic dosage forms

Solution Indication Surface tension (dynes/cm)
Mucosal lining fluid   ~56
Afrin® No Drip Extra Moisturizing Relieves nasal congestion due to common cold, hay fever, upper respiratory allergies; swollen nasal membranes, sinus congestion/pressure 44.7 ± 0.8
Afrin® Original Nasal Spray Relieves nasal congestion due to common cold, hay fever, upper respiratory allergies; swollen nasal membranes, sinus congestion/pressure 41.6 ± 0.3
CareOne® No Drip Nasal Spray Relieves nasal congestion; sinus congestion 40.6 ± 0.4
Zicam® Intense Sinus Relief No Drip Liquid Nasal Gel Relieves nasal congestion due to common cold, hay fever, allergies, and sinusitis; sinus congestion/pressure 37.4 ± 0.6
Mucinex® Sinus-Max Relieves nasal congestion, due to common cold, hay fever, upper respiratory allergies; sinus congestion/pressure 37.2 ± 0.4
4 Way® Nasal Decongestant Fast Acting Spray Relieves nasal congestion, sinus congestion/pressure, swollen nasal membranes 36.7 ± 0.4
Vicks® Sinex 12 Hour Decongestant Nasal Spray Relieves nasal congestion due to cold, hay fever, upper respiratory allergies 33.9 ± 0.2
NeoSynephrine® Cold & Sinus Mild Strength Spray Relieves nasal congestion due to cold, allergies 33.8 ± 0.2
CareOne® Saline Nasal Spray—Nasal Moisturizing Spray Relieves dry nasal membranes 33.1 ± 0.2
Vicks® Non-Drowsy Qlear Quil 12 Hour Nasal Decong. Moisturizing Relieves nasal congestion due to cold, hay fever, other respiratory allergies; sinus congestion/pressure 30.3 ± 0.2