The octanol/water distribution coefficients of ardipusilloside-I and its metabolites, and their permeation characteristics across Caco-2 cell monolayer

Table 2 The P_app values of ADS-I, M1 and M2 at different concentrations across the Caco-2 cell monolayer in both directions in 120 min

Compound	Concentration (µmol/L)	Papp/× 10⁻⁶ cm·s⁻¹		Efflux ratio
Compound	Concentration (µmol/L)	AP → BL	BL → AP	Efflux ratio
ADS-I	2	6.66 ± 1.32	2.50 ± 0.53	0.38
	5	3.10 ± 0.33	1.66 ± 0.24	0.54
	10	1.88 ± 0.21	0.69 ± 0.15	0.37
M1	2	9.13^** ± 1.65	3.14^** ± 0.58	0.34
	5	6.07^** ± 0.74	3.45^** ± 0.67	0.57
	10	4.30^** ± 0.43	1.76^** ± 0.26	0.41
M2	2	10.48^** ± 1.21	4.53^** ± 0.57	0.43
	5	6.76^** ± 0.85	2.60^** ± 0.43	0.38
	10	4.74^** ± 0.47	2.12^** ± 0.23	0.45

Date are presented as mean ± SD (n = 3). ^** P < 0.01 compared to control group (ADS-I)

ISSN: 2661-801X