Table 9 ADMET descriptor models
Name of the ADMET model | Prediction levels |
|---|---|
Human intestinal absorption | 0 (Good absorption) |
1 (Moderate absorption) | |
2 (Low absorption) | |
3 (Very low absorption) | |
Aqueous solubility | 0 (Extremely low) |
1 (No, very low, but possible) | |
2 (Yes, low) | |
3 (Yes, good) | |
4 (Yes, optimal) | |
5 (Too soluble) | |
Blood brain barrier (BBB) | 0 (Very high penetration) |
1 (High penetration) | |
2 (Medium penetration) | |
3 (Low penetration) | |
4 (Undefined penetration) | |
Cytochrome P450 2D6 (CYP 2D6) | 0 (Non−inhibitor) |
1 (Inhibitor) | |
Hepatotoxicity | 0 (Nontoxic) |
1 (Toxic) | |
Plasma protein binding (PBB) | 0 (Binding is <90 %) |
1 (Binding is >90 %) | |
2 (Binding is >95 % |