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Table 2 Antiviral activity against HSVand CVB4 of compounds (128) in terms of CC50, EC50 (μg/mL) and SI

From: Molecular docking study and antiviral evaluation of 2-thioxo-benzo[g]quinazolin-4(3H)-one derivatives

Cpd Nr. CC50 HSV-1 HSV-2 CVB4  
EC50 SI EC50 SI EC50 SI
1 115.9 Inactive Inactive Inactive Inactive 272.4 0.43
2 173.1 247.5 0.70 213.8 0.81 149.2 1.16
3 376.5 428.1 0.88 361.6 1.04 342.4 1.10
4 824.7 706.4 1.17 649.2 1.27 478.9 1.72
5 3840 896.4 4.28 740.8 5.18 612.8 6.27
6 261.4 224.5 1.16 208.9 1.25 102.9 2.54
7 105.7 73.8 1.43 81.4 1.30 38.9 2.72
8 218.5 147.1 1.49 159.6 1.37 93.6 2.33
9 546.9 316.5 1.73 359.2 1.52 94.8 5.77
10 198.9 162.7 1.22 184.3 1.08 124.1 1.60
11 542.6 403.9 1.34 467.3 1.16 216.2 2.51
12 83.7 74.12 1.13 65.9 1.27 56.4 1.48
13 652.4 594.6 1.10 681.3 0.96 371.8 1.75
14 221.8 197.3 1.12 176.4 1.26 116.8 1.90
15 376.2 243.2 1.55 260.8 1.44 104.6 3.60
16 934.2 582.9 1.60 624.6 1.50 316.4 2.95
17 132.7 81.2 1.63 104.8 1.27 50.2 2.64
18 183.4 149.8 1.22 140.5 1.31 89.5 2.05
19 236.5 189.3 1.25 174.9 1.35 157.1 1.51
20 465.3 369.1 1.26 402.9 1.15 287.6 1.62
21 968.7 674.8 1.44 812.6 1.19 259.4 3.73
22 127.3 76.3 1.67 89.4 1.42 41.2 3.09
23 205.6 183.6 1.12 165.2 1.24 149.2 1.38
24 169.1 64.7 2.61 112.3 1.51 43.9 3.85
25 431.6 307.2 1.40 284.8 1.52 204.3 2.11
26 681.2 498.2 1.37 514.6 1.32 395.6 1.72
27 1034.8 >1000 Inactive >1000 Inactive 475.3 2.17
28 189.6 162.4 1.17 178.6 1.06 57.3 3.31
Acyclovir 648.2 2.3 281.83 1.06 144.04
Ribavirin 486.4 11.6 41.93 11.3 24.69 29.7 16.38
  1. Cells treated with DMSO (0.1 %) were used as a negative control, and its reading was subtracted from the readings of tested compounds. Statistics were calculated using one-way ANOVA