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Fig. 6 | Chemistry Central Journal

Fig. 6

From: Enhanced preferential cytotoxicity through surface modification: synthesis, characterization and comparative in vitro evaluation of TritonX-100 modified and unmodified zinc oxide nanoparticles in human breast cancer cell (MDA-MB-231)

Fig. 6

Mean cell viability of (a) ZnO and (b) modified ZnO treatment on MDA-MB-231 and NIH 3T3. Both cells were treated with ZnO NPs at concentration gradient from 200 to 12.5 μg/mL for 24 h. Corresponding absorbance reading ofdissolved formazan was taken after its conversion by viable cells which was plotted with respect to control (untreated cells) against concentration gradient. Mean ± SE plot shows concentration dependent toxicity for MDA-MB-231 cell whereas no strong positive correlation was found in normal NIH 3T3 cell. Percent viability was also found relatively higher in case of normal NIH 3T3 than MDA-MB-231 at given concentration. Two factor ANOVA with α = 0.05 was performed for effectiveness of ZnO NPs between two cell lines and p value for interaction was found to be less than 0.05 verifying difference in effectiveness of NPs on these two cell lines

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