Scheme 1From: Synthesis and biological evaluation of new 1,3-thiazolidine-4-one derivatives of nitro-l-arginine methyl esterSynthesis of compounds 6a–j. Reagents and conditions: a DIPEA, toluene, reflux 24–30 h; b KOH 1 M, EtOH/THF (1/1), r.t. 8–12 h then HCl 1 M; c N ω -nitro-l-arginine methyl ester hydrochloride (5), HOBt, EDC, DCM, r.t. 10–15 hBack to article page